Onset of coeliac disease during treatment with interferon for chronic hepatitis C.

Giovanni Cammarota, Rossella Cianci, Franco Pandolfi, Giovanni Battista Gasbarrini, Lucio Cuoco

Research output: Contribution to journalArticle

Abstract

The immunomodulatory properties of interferon may concur to precipitate or worsen an underlying autoimmune disorders. We report the cases of two men who displayed the various features of coeliac disease during a treatment with 4-interferon (in one case associated with ribavirin) for chronic hepatitis C. The patients stopped the interferon treatment and the symptoms and histological disorders improved after a gluten-free diet. Alpha-interferon is available worldwide for treatment of chronic viral hepatitis. Before treatment with this drug, the patients would have to be monitored for coeliac disease.
Original languageEnglish
Pages (from-to)5-1494
Number of pages1490
JournalThe Lancet
Publication statusPublished - 2000

Keywords

  • celiac disease
  • chronic Hepatitis

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