Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature

Angelo Minucci, Ettore Domenico Capoluongo, Gian Luca Rampioni Vinciguerra, Niccolò Noccioli, Claudia Cippitelli, Armando Bartolazzi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.
Original languageEnglish
Pages (from-to)166-168
Number of pages3
JournalRare Tumors
Volume8
DOIs
Publication statusPublished - 2016

Keywords

  • Medullary carcinoma
  • Thyroid

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