Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment

Simona Serini, Roberta Cassano, Federica Curcio, Sonia Trombino, Gabriella Calviello

Research output: Contribution to journalArticlepeer-review


Different strategies have been investigated for a more satisfactory treatment of advanced breast cancer, including the adjuvant use of omega-3 polyunsaturated fatty acids (PUFAs). These nutritional compounds have been shown to possess potent anti-inflammatory and antiangiogenic activities, the capacity to affect transduction pathways/receptors involved in cell growth and to reprogram tumor microenvironment. Omega-3 PUFA-containing nanoformulations designed for drug delivery in breast cancer were shown to potentiate the effects of enclosed drugs, enhance drug delivery to target sites, and minimize drug-induced side effects. We have critically analyzed here the results of the most recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer. The anti-neoplastic efficacy of omega-3 PUFAs has also been convincingly demonstrated by using preclinical in vivo models of ovarian cancer. The results obtained are critically analyzed here and seem to provide a sufficient rationale to move to still lacking interventional clinical trials, as well as to evaluate possible advantages of enclosing omega-3 PUFAs to drug-delivery nanosystems for ovarian cancer. Future perspectives in this area are also provided.
Original languageEnglish
Pages (from-to)12032-N/A
Number of pages16
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2022


  • Breast
  • Breast Neoplasms
  • Carcinoma, Ovarian Epithelial
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Female
  • Humans
  • Ovarian Neoplasms
  • Tumor Microenvironment
  • breast cancer
  • in vitro studies
  • nanoformulations
  • omega-3 PUFA
  • ovarian cancer
  • preclinical studies


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