Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis

Paolo Montuschi; Debor Paris; Silvi Montella; Dominiqu Melck; Virgini Mirra; Giusepp Santini; Nadia Mores; Enz Montemitro; Fabi Majo; Vincenzin Lucidi; Andre Bush; Andre Motta; Francesc Santamaria

doi:10.1164/rccm.201402-0249LE

Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis

Paolo Montuschi, Debor Paris, Silvi Montella, Dominiqu Melck, Virgini Mirra, Giusepp Santini, Nadia Mores, Enz Montemitro, Fabi Majo, Vincenzin Lucidi, Andre Bush, Andre Motta, Francesc Santamaria

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	190
DOIs	https://doi.org/10.1164/rccm.201402-0249LE
Publication status	Published - 2014

Keywords

Cystic fibrosis
Exhaled breath condensate
Metabolomics
NMR spectroscopy
Personalised medicine
Primary ciliary dyskinesia

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10.1164/rccm.201402-0249LE

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Montuschi, P., Paris, D., Montella, S., Melck, D., Mirra, V., Santini, G., Mores, N., Montemitro, E., Majo, F., Lucidi, V., Bush, A., Motta, A., & Santamaria, F. (2014). Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 190, 229-233. https://doi.org/10.1164/rccm.201402-0249LE

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title = "Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis",

abstract = "The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.",

keywords = "Cystic fibrosis, Exhaled breath condensate, Metabolomics, NMR spectroscopy, Personalised medicine, Primary ciliary dyskinesia, Cystic fibrosis, Exhaled breath condensate, Metabolomics, NMR spectroscopy, Personalised medicine, Primary ciliary dyskinesia",

author = "Paolo Montuschi and Debor Paris and Silvi Montella and Dominiqu Melck and Virgini Mirra and Giusepp Santini and Nadia Mores and Enz Montemitro and Fabi Majo and Vincenzin Lucidi and Andre Bush and Andre Motta and Francesc Santamaria",

year = "2014",

doi = "10.1164/rccm.201402-0249LE",

language = "English",

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pages = "229--233",

journal = "American Journal of Respiratory and Critical Care Medicine",

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Montuschi, P, Paris, D, Montella, S, Melck, D, Mirra, V, Santini, G, Mores, N, Montemitro, E, Majo, F, Lucidi, V, Bush, A, Motta, A & Santamaria, F 2014, 'Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis', American Journal of Respiratory and Critical Care Medicine, vol. 190, pp. 229-233. https://doi.org/10.1164/rccm.201402-0249LE

TY - JOUR

T1 - Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis

AU - Montuschi, Paolo

AU - Paris, Debor

AU - Montella, Silvi

AU - Melck, Dominiqu

AU - Mirra, Virgini

AU - Santini, Giusepp

AU - Mores, Nadia

AU - Montemitro, Enz

AU - Majo, Fabi

AU - Lucidi, Vincenzin

AU - Bush, Andre

AU - Motta, Andre

AU - Santamaria, Francesc

PY - 2014

Y1 - 2014

N2 - The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.

AB - The respiratory phenotypes of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are different, with PCD showing much slower progression. Nuclear magnetic resonance (NMR)-based metabolomics of exhaled breath condensate (EBC) recognizes markers separating children with asthma or adults with chronic obstructive pulmonary disease from healthy subjects and unstable from stable CF. No NMR studies in PCD have been reported, and whether EBC metabolic profiles in PCD differ from CF is unknown. In thuis cross-sectional stud we aimed to determine if NMR might be useful in discriminating between PCD and CF and possibly identify selective metabolites accounting for their differing prognoses.

KW - Cystic fibrosis

KW - Exhaled breath condensate

KW - Metabolomics

KW - NMR spectroscopy

KW - Personalised medicine

KW - Primary ciliary dyskinesia

KW - Cystic fibrosis

KW - Exhaled breath condensate

KW - Metabolomics

KW - NMR spectroscopy

KW - Personalised medicine

KW - Primary ciliary dyskinesia

UR - http://hdl.handle.net/10807/60948

U2 - 10.1164/rccm.201402-0249LE

DO - 10.1164/rccm.201402-0249LE

M3 - Article

SN - 1073-449X

VL - 190

SP - 229

EP - 233

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

ER -

Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis

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