NON-NATURAL SEMAPHORINS 3 AND THEIR MEDICAL USE

Guido Serini (Inventor), Enrico Giraudo (Inventor), Luca Tamagnone (Inventor)

Research output: Patent

Abstract

The present invention relates to non-naturally occurring, mutated Semaphorin 3 molecules. Particularly, the invention relates to the mutated Semaphorin 3 or the functional fragment thereof that exhibit improved properties and pharmacologic effects, e.g., in the treatment of angiogenic disease and cancer. In addition, the present invention relates to nucleic acid molecules encoding such polypeptides, and vectors and hosts comprising such nucleic acids. The invention further relates to methods for producing the polypeptides of the invention, and to methods of using them in the treatment of disease, in particular in the medical intervention of angiogenic diseases, tumors and/or cancer.
Original languageEnglish
Patent numberWO/2016/135130
Publication statusPublished - 21 Jun 2016

Keywords

  • Angiogenesis
  • Cancer
  • Endothelial cells
  • Plexins
  • Semaphorins

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