Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women

Giovanni Scambia, Nicoletta Di Simone

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In post-menopausal period vulvo-vaginal atrophy (VVA)-related symptoms may seriously affect women's quality of life. Hormonal replacement therapy effectively relieves these symptoms but it is not always safe or accepted, and a non-hormonal treatment is often needed instead. Over a period of 12 weeks, we tested the effect of a twice-a-week vulvo-vaginal application of a hyaluronic acid, AC collagen, isoflavones and vitamins-based cream (Perilei Pausa()) on 35 women in post-menopausal period, reporting VVA-related symptoms. After 12 weeks of treatment with Perilei Pausa() a significant improvement in vaginal dryness, vulvo-vaginal itching, dyspareunia (P < 0.001), dysuria (P = 0.02), nocturia (P = 0.009) and pollakiuria (P = 0.005) was reported by the women. Colposcopical score assessing the intensity of atrophic colpitis, cervico-vaginal paleness and petechiae was also reduced (P = 0.037, P = 0.016 and P = 0.032, respectively). No significant difference in terms of maturation value of cervico-vaginal epithelium was observed. In conclusion, Perilei Pausa() may represent an effective and safe alternative treatment of symptomatic VVA in post-menopausal women.
Original languageEnglish
Pages (from-to)835-838
Number of pages4
JournalJournal of Obstetrics and Gynaecology
Volume35
Publication statusPublished - 2015

Keywords

  • post-menopausal
  • vulvo-vaginal

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