Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity

Franca Tecchio; Fabrizio Vecchio; Mariacarla Ventriglia; Camillo Porcaro; Francesca Miraglia; Mariacristina Siotto; Paolo Maria Rossini; Mauro Rongioletti; Rosanna Squitti

doi:10.2174/1567205013666160603001131

Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity

Franca Tecchio, Fabrizio Vecchio, Mariacarla Ventriglia, Camillo Porcaro, Francesca Miraglia, Mariacristina Siotto, Paolo Maria Rossini, Mauro Rongioletti, Rosanna Squitti

Università Cattolica del Sacro Cuore

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).

Original language	English
Pages (from-to)	1374-1384
Number of pages	11
Journal	Current Alzheimer Research
Volume	13
DOIs	https://doi.org/10.2174/1567205013666160603001131
Publication status	Published - 2016

Keywords

Non-Ceruloplasmin

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10.2174/1567205013666160603001131

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title = "Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity",

abstract = "Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).",

keywords = "Non-Ceruloplasmin, Non-Ceruloplasmin",

author = "Franca Tecchio and Fabrizio Vecchio and Mariacarla Ventriglia and Camillo Porcaro and Francesca Miraglia and Mariacristina Siotto and Rossini, {Paolo Maria} and Mauro Rongioletti and Rosanna Squitti",

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doi = "10.2174/1567205013666160603001131",

language = "English",

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T1 - Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity

AU - Tecchio, Franca

AU - Vecchio, Fabrizio

AU - Ventriglia, Mariacarla

AU - Porcaro, Camillo

AU - Miraglia, Francesca

AU - Siotto, Mariacristina

AU - Rossini, Paolo Maria

AU - Rongioletti, Mauro

AU - Squitti, Rosanna

PY - 2016

Y1 - 2016

N2 - Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).

AB - Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).

KW - Non-Ceruloplasmin

UR - http://hdl.handle.net/10807/92782

U2 - 10.2174/1567205013666160603001131

DO - 10.2174/1567205013666160603001131

M3 - Article

SN - 1567-2050

VL - 13

SP - 1374

EP - 1384

JO - Current Alzheimer Research

JF - Current Alzheimer Research

ER -

Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity

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Keywords

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