NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

Simona Caruso; Biagio De Angelis; Simona Carlomagno; Francesca Del Bufalo; Simona Sivori; Franco Locatelli; Concetta Quintarelli

doi:10.1053/j.seminhematol.2020.10.004

NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

Simona Caruso
, Biagio De Angelis
, Simona Carlomagno
, Francesca Del Bufalo
, Simona Sivori
, Franco Locatelli
, Concetta Quintarelli

IRCCS Ospedale pediatrico Bambino Gesù - Roma
University of Genoa

Research output: Contribution to journal › Article

Abstract

Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

Original language	English
Pages (from-to)	175-184
Number of pages	10
Journal	Seminars in Hematology
Volume	57
DOIs	https://doi.org/10.1053/j.seminhematol.2020.10.004
Publication status	Published - 2020

Keywords

CAR
Genetic modification
HSC transplantation
Immunotherapy
KIRs
NK cell

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10.1053/j.seminhematol.2020.10.004

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title = "NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles",

abstract = "Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic {\textquotedblleft}off-the-shelf{\textquotedblright} adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.",

keywords = "CAR, Genetic modification, HSC transplantation, Immunotherapy, KIRs, NK cell, CAR, Genetic modification, HSC transplantation, Immunotherapy, KIRs, NK cell",

author = "Simona Caruso and \{De Angelis\}, Biagio and Simona Carlomagno and \{Del Bufalo\}, Francesca and Simona Sivori and Franco Locatelli and Concetta Quintarelli",

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doi = "10.1053/j.seminhematol.2020.10.004",

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T1 - NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

AU - Caruso, Simona

AU - De Angelis, Biagio

AU - Carlomagno, Simona

AU - Del Bufalo, Francesca

AU - Sivori, Simona

AU - Locatelli, Franco

AU - Quintarelli, Concetta

PY - 2020

Y1 - 2020

N2 - Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

AB - Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

KW - CAR

KW - Genetic modification

KW - HSC transplantation

KW - Immunotherapy

KW - KIRs

KW - NK cell

KW - CAR

KW - Genetic modification

KW - HSC transplantation

KW - Immunotherapy

KW - KIRs

KW - NK cell

UR - http://hdl.handle.net/10807/228318

U2 - 10.1053/j.seminhematol.2020.10.004

DO - 10.1053/j.seminhematol.2020.10.004

M3 - Article

SN - 0037-1963

VL - 57

SP - 175

EP - 184

JO - Seminars in Hematology

JF - Seminars in Hematology

ER -

NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

Abstract

Keywords

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