NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl‑glutathione‑coated gold nanoparticles

Roberto Piacentini, Claudio Grassi, Antonio Buonerba, Rosita Lapenta, Anna Donniacuo, Magda Licasale, Elena Vezzoli, Stefano Milione, Carmine Capacchione, Mario Felice Tecce, Andrea Falqui, Alfonso Grassi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect
Original languageEnglish
Pages (from-to)N/A-N/A
Number of pages14
JournalScientific Reports
Volume2020
DOIs
Publication statusPublished - 2020

Keywords

  • NIR multiphoton ablation
  • cancer cells

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