Neurotrophic features of human adipose tissue-derived stromal cells: in vitro and in vivo studies

Wanda Lattanzi, Maria Concetta Geloso, Stefano Giannetti, Valentina Corvino, Antonio Gasbarrini, Nathalie Saulnier, Maria Ausiliatrice Puglisi, Fabrizio Michetti

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Due to its abundance, easy retrieval, and plasticity characteristics, adipose-tissue-derived stromal cells (ATSCs) present unquestionable advantages over other adult-tissue-derived stem cells. Based on the in silico analysis of our previous data reporting the ATSC-specific expression profiles, the present study attempted to clarify and validate at the functional level the expression of the neurospecific genes expressed by ATSC both in vitro and in vivo. This allowed evidencing that ATSCs express neuro-specific trophins, metabolic genes, and neuroprotective molecules. They were in fact able to induce neurite outgrowth in vitro, along with tissue-specific commitment along the neural lineage and the expression of the TRKA neurotrophin receptor in vivo. Our observation adds useful information to recent evidence proposing these cells as a suitable tool for cell-based applications in neuroregenerative medicine.
Original languageEnglish
Pages (from-to)N/A-N/A
Number of pages9
JournalJournal of Biomedicine and Biotechnology
Volume2011
Publication statusPublished - 2011

Keywords

  • Neurotrophic
  • stromal cells

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