Neuropsychological Deterioration Predicts Tumor Progression in a Young Boy With Bithalamic Glioma

Antonio Ruggiero, Cesare Colosimo, Maria Chiara Stefanini, Riccardo Riccardi, Maria Chiara Stefanini, Riccardo Riccardi, Laura Iuvone

Research output: Contribution to journalArticle

2 Citations (Scopus)


A description is given of the clinical, neuropsychological, and neuroimaging evolution of a 12-year-old boy (CG) who presented with bilateral thalamic astrocytoma (World Health Organization Grade 2). CG underwent an extensive neuropsychological assessment immediately after biopsy prior to any medical therapies and was followed up for 3 years until death. Neuropsychological functioning was thoroughly investigated by means of a detailed battery that included intelligence and cognitive functions. Evolution was characterized by cognitive deterioration that preceded neuroimaging signs of tumor progression. Starting from normal cognitive organization, the child exhibited visuospatial memory deficits and, afterward, diffuse cognitive impairment. The role of neuropsychological assessment in detecting early disease progression is discussed, mainly for rare pathologies whose evolution may be extremely variable.
Original languageEnglish
Pages (from-to)76-81
Number of pages6
Publication statusPublished - 2016


  • Astrocytoma
  • Brain Neoplasms
  • Child
  • Cognition Disorders
  • Developmental and Educational Psychology
  • Disease Progression
  • Fatal Outcome
  • Humans
  • Male
  • Neuropsychological Tests
  • Neuropsychology and Physiological Psychology
  • Prognosis
  • Thalamus
  • bithalamic tumor
  • children
  • cognitive deterioration
  • neuropsychological assessment
  • progressive neurological diseases
  • visual spatial memory


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