Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4

Guido Rindi, Valentina Damato, Mario Sabatelli, Raffaele Iorio, Carmen Erra, Michela Ada Noris Ferilli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The observations of neuromyelitis optica spectrum disorders (NMOSD) occurring in the setting of cancer suggest that aquaporin-4 (AQP4) autoimmunity may in some cases be paraneoplastic. Results: We describe a 72-year-old patient who developed a longitudinally extensive transverse myelitis associated with AQP4 autoantibodies in the setting of a lung adenocarcinoma recurrence. AQP4 expression was demonstrated in tumor cells. IgG in patients cerebrospinal fluid bound to tumor cells co-localizing with AQP4 immunoreactivity. Conclusions and relevance: This case expands the spectrum of paraneoplastic AQP4 autoimmunity highlighting the importance of considering an oncological screening in patients with late-onset NMOSD.
Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalMultiple Sclerosis
Volume21
DOIs
Publication statusPublished - 2015

Keywords

  • Adenocarcinoma
  • Aged
  • Aquaporin 4
  • Autoantibodies
  • Humans
  • Lung Neoplasms
  • Male
  • Medicine (all)
  • Myelitis, Transverse
  • Neoplasm Recurrence, Local
  • Neurology
  • Neurology (clinical)
  • Paraneoplastic
  • neuromyelitis optica

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