Neuroendocrinologia dei disturbi dell umore

Translated title of the contribution: [Autom. eng. transl.] Neuroendocrinology of mood disorders

Luigi Janiri, Marianna Mazza, Pietro Bria, Salvatore Mazza

Research output: Contribution to journalArticlepeer-review


Mood disorders represent the most widespread prevalent and expensive psychiatric disorders. For a long time, the neuroendocrine system and the distribution of hormones through the brain and their modulatory role and influence in behavior and mood have been studied. The most important changes associated with mood disorders concern the hypothalamic-pituitaryadrenal (HPA), the hypothalamic-pituitary-thyroid (HPT), the hypothalamic-pituitary-GH (HPGH) and the hypothalamic-pituitary-gonadal (HPGn) axes. The intriguing data obtained from studies focusing on central neuropeptidergic circuits and peripheral hormone systems have been very useful in understanding the pathophysiology of mood disorders, although additional researches are needed to confirm these findings. All these data underline the importance of neuroendocrine dysfunctions in both pathophysiology of mood disorders and in the development of new pharmacotherapies.
Translated title of the contribution[Autom. eng. transl.] Neuroendocrinology of mood disorders
Original languageItalian
Pages (from-to)11-24
Number of pages14
JournalMinerva Psichiatrica
Publication statusPublished - 2006


  • HPA axis
  • Mood disorders
  • Neuroendocrine system
  • disturbi dell'umore
  • neuroendocrinologia


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