Neural dynamics of neglected targets in patients with right hemisphere damage

Federica Rastelli, Raffaella Migliaccio, Monica Narcisa Toba, Paolo Bartolomeo, Catherine Tallon-Baudry, Monica N. Toba, Antoine Ducorps, Pascale Pradat-Diehl, Christophe Duret, Bruno Dubois, Antoni Valero-Cabré

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We studied the neural correlates of target omissions in five patients with right hemisphere damage and varying signs of left spatial neglect. Benefiting from the high temporal resolution of magneto-encephalography, we directly compared brain regional synchrony events of detected and omitted left-sided targets. Results showed that before stimulus presentation, a low beta synchronization activity was specifically increased within left frontal areas before pathological response omissions of left-sided targets. In the same pre-stimulus period, there were no such beta oscillations when patients correctly detected the target, or when no target was presented. Our findings emphasize the importance of neural activity during the pre-stimulus period on subsequent stimulus processing, and highlight the consequences of episodic interruptions of large-scale interhemispheric networks on target detection. Furthermore, our data suggest that prefrontal activity is not necessarily beneficial to target detection, but can be detrimental to it.
Original languageEnglish
Pages (from-to)1989-1996
Number of pages8
JournalCortex
Volume49
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • neglect

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