TY - JOUR
T1 - Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections
AU - Casciaro, Bruno
AU - Mangiardi, Laura
AU - Cappiello, Floriana
AU - Romeo, Isabella
AU - Loffredo, Maria Rosa
AU - Iazzetti, Antonia
AU - Calcaterra, Andrea
AU - Goggiamani, Antonella
AU - Ghirga, Francesca
AU - Mangoni, Maria Luisa
AU - Botta, Bruno
AU - Quaglio, Deborah
PY - 2020
Y1 - 2020
N2 - Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure-function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.
AB - Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure-function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.
KW - Alkaloids
KW - Antibiotic resistance
KW - Antimicrobials
KW - Methicillin-resistant staphylococcus aureus
KW - Natural products
KW - Plant-derived alkaloids
KW - Structure-activity relationship
KW - Vancomycin-resistant enterococci
KW - Alkaloids
KW - Antibiotic resistance
KW - Antimicrobials
KW - Methicillin-resistant staphylococcus aureus
KW - Natural products
KW - Plant-derived alkaloids
KW - Structure-activity relationship
KW - Vancomycin-resistant enterococci
UR - http://hdl.handle.net/10807/198668
U2 - 10.3390/molecules25163619
DO - 10.3390/molecules25163619
M3 - Article
SN - 1420-3049
VL - 25
SP - 3619
EP - 3652
JO - Molecules
JF - Molecules
ER -
