Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera

Massimiliano Papi; P. Paoletti; B. Geraghty; R. Akhtar

doi:10.1063/1.4868388

Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera

Massimiliano Papi, P. Paoletti, B. Geraghty, R. Akhtar

School of Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We apply the PeakForce Quantitative Nanomechanical Property Mapping (PFQNM) atomic force microscopy mode for the investigation of regional variations in the nanomechanical properties of porcine sclera. We examine variations in the collagen fibril diameter, adhesion, elastic modulus and dissipation in the posterior, equatorial and anterior regions of the sclera. The mean fibril diameter, elastic modulus and dissipation increased from the posterior to the anterior region. Collagen fibril diameter correlated linearly with elastic modulus. Our data matches the known macroscopic mechanical behavior of the sclera. We propose that PFQNM has significant potential in ocular biomechanics and biophysics research.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Applied Physics Letters
DOIs	https://doi.org/10.1063/1.4868388
Publication status	Published - 2014

Keywords

COLLAGEN
SCLERA

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10.1063/1.4868388

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title = "Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera",

abstract = "We apply the PeakForce Quantitative Nanomechanical Property Mapping (PFQNM) atomic force microscopy mode for the investigation of regional variations in the nanomechanical properties of porcine sclera. We examine variations in the collagen fibril diameter, adhesion, elastic modulus and dissipation in the posterior, equatorial and anterior regions of the sclera. The mean fibril diameter, elastic modulus and dissipation increased from the posterior to the anterior region. Collagen fibril diameter correlated linearly with elastic modulus. Our data matches the known macroscopic mechanical behavior of the sclera. We propose that PFQNM has significant potential in ocular biomechanics and biophysics research.",

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author = "Massimiliano Papi and P. Paoletti and B. Geraghty and R. Akhtar",

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doi = "10.1063/1.4868388",

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journal = "Applied Physics Letters",

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publisher = "American Institute of Physics:2 Huntington Quadrangle, Suite 1NO1:Melville, NY 11747:(800)344-6902, (631)576-2287, EMAIL: [email protected], INTERNET: http://www.aip.org, Fax: (516)349-9704",

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T1 - Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera

AU - Papi, Massimiliano

AU - Paoletti, P.

AU - Geraghty, B.

AU - Akhtar, R.

PY - 2014

Y1 - 2014

N2 - We apply the PeakForce Quantitative Nanomechanical Property Mapping (PFQNM) atomic force microscopy mode for the investigation of regional variations in the nanomechanical properties of porcine sclera. We examine variations in the collagen fibril diameter, adhesion, elastic modulus and dissipation in the posterior, equatorial and anterior regions of the sclera. The mean fibril diameter, elastic modulus and dissipation increased from the posterior to the anterior region. Collagen fibril diameter correlated linearly with elastic modulus. Our data matches the known macroscopic mechanical behavior of the sclera. We propose that PFQNM has significant potential in ocular biomechanics and biophysics research.

AB - We apply the PeakForce Quantitative Nanomechanical Property Mapping (PFQNM) atomic force microscopy mode for the investigation of regional variations in the nanomechanical properties of porcine sclera. We examine variations in the collagen fibril diameter, adhesion, elastic modulus and dissipation in the posterior, equatorial and anterior regions of the sclera. The mean fibril diameter, elastic modulus and dissipation increased from the posterior to the anterior region. Collagen fibril diameter correlated linearly with elastic modulus. Our data matches the known macroscopic mechanical behavior of the sclera. We propose that PFQNM has significant potential in ocular biomechanics and biophysics research.

KW - COLLAGEN

KW - SCLERA

KW - COLLAGEN

KW - SCLERA

UR - http://hdl.handle.net/10807/56018

U2 - 10.1063/1.4868388

DO - 10.1063/1.4868388

M3 - Article

SN - 0003-6951

SP - 1

EP - 4

JO - Applied Physics Letters

JF - Applied Physics Letters

ER -

Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera

Abstract

Keywords

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