n-3 PUFA and alpha-tocopherol control of tumor
cell proliferation.

Paola Palozza; Elisabetta Piccioni; Marcello Anti; Bartoli Gm; G Marra; F Armelao; P Franceschelli; C Luberto; E Sgarlata

n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.

Paola Palozza, Elisabetta Piccioni, Marcello Anti, Bartoli Gm, G Marra, F Armelao, P Franceschelli, C Luberto, E Sgarlata

Faculty of Medicine and Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E

Original language	English
Pages (from-to)	247-252
Number of pages	6
Journal	Molecular Aspects of Medicine
Publication status	Published - 1993

Keywords

alpha-tocopherol
cell proliferation
n-3 PUFA

Cite this

@article{6afae8a65cf547b3a5ccc2d2326fdeff,

title = "n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.",

abstract = "Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E",

keywords = "alpha-tocopherol, cell proliferation, n-3 PUFA, alpha-tocopherol, cell proliferation, n-3 PUFA",

author = "Paola Palozza and Elisabetta Piccioni and Marcello Anti and Bartoli Gm and G Marra and F Armelao and P Franceschelli and C Luberto and E Sgarlata",

year = "1993",

language = "English",

pages = "247--252",

journal = "Molecular Aspects of Medicine",

issn = "0098-2997",

publisher = "Oxford: Elsevier Science Limited Oxford; New York: Pergamon Press 1976-",

}

TY - JOUR

T1 - n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.

AU - Palozza, Paola

AU - Piccioni, Elisabetta

AU - Anti, Marcello

AU - Gm, Bartoli

AU - Marra, G

AU - Armelao, F

AU - Franceschelli, P

AU - Luberto, C

AU - Sgarlata, E

PY - 1993

Y1 - 1993

N2 - Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E

AB - Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E

KW - alpha-tocopherol

KW - cell proliferation

KW - n-3 PUFA

KW - alpha-tocopherol

KW - cell proliferation

KW - n-3 PUFA

UR - http://hdl.handle.net/10807/23835

M3 - Article

SP - 247

EP - 252

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

SN - 0098-2997

ER -

n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.

Abstract

Keywords

Other files and links

Fingerprint

Cite this