Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Amelia Evoli, Valentina Damato, Paolo Emilio Alboini, Raffaele Iorio, Marco Luigetti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Abstract The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies. We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies.
Original languageEnglish
Pages (from-to)646-650
Number of pages5
JournalNeuromuscular Disorders
Volume25
DOIs
Publication statusPublished - 2015

Keywords

  • 3,4-diaminopyridine
  • Cholinesterase inhibitors
  • Lambert-Eaton myasthenic syndrome
  • Myasthenia gravis

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