Mutations of the BIK gene in human peripheral B-cell lymphomas

Vincenzo Arena, Maurizio Martini, Arnaldo Capelli, Luigi Maria Larocca, Myriam Luongo

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

BIK, a BH (Bcl2 homology domain)3-only protein, is a proapoptotic member of the BCL2 family. We performed single-strand conformational polymorphism and sequencing analysis of the entire coding region of the BIK gene (exons 2-5) in 71 B-cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B-cell lymphomas (DLBCLs)]. Missense BIK gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in 1 of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the BIK gene is a frequent feature of B-cell lymphomas.
Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalGENES, CHROMOSOMES & CANCER
Volume38
DOIs
Publication statusPublished - 2003

Keywords

  • Apoptosis
  • Apoptosis Regulatory Proteins
  • DNA Mutational Analysis
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lymphoma, B-Cell
  • Membrane Proteins
  • Mutation
  • Neoplasm Proteins
  • Polymorphism, Single-Stranded Conformational
  • Proteins

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