Muscle strength is related to mental and physical quality of life in the oldest old

Silvia Giovannini, Luca Padua, Claudia Loreti, Daniele Coraci, Alice Laudisio, Panaiotis Finamore, Federica Vannetti, Raffaele Antonelli Incalzi, Claudio Macchi, Roberta Boni, Chiara Castagnoli, Francesca Cecchi, Francesca Cesari, Francesco Epifani, Roberta Frandi, Betti Giusti, Maria Luisa Eliana Luisi, Rossella Marcucci, Raffaello Molino-Lova, Anita PaperiniLorenzo Razzolini, Francesco Sofi, Nona Turcan, Debora Valecchi

Research output: Contribution to journalArticle

2 Citations (Scopus)


Purpose of the study: Quality of life represents the principal outcome of health interventions for the oldest old. However, little is known about the determinants of quality of life in this population stratum. We evaluated the association between health-related quality of life (HRQoL) and handgrip strength in a cohort of 331 participants aged 90+ with a living in the Mugello area (Tuscany, Italy). Design and methods: HRQoL was assessed using the Medical Outcomes Study Short Form 12 (SF12), considering the Physical Composite Score (PCS) and the Mental Composite Score (MCS) of the SF-12. Muscle strength was tested by hand grip dynamometry. Results: The median MCS was 46.9, while the median PCS was 43.0. According to logistic regression, muscle strength was associated with increased probability of better PCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .042), and better MCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .036), after adjusting. Implication: Muscle strength is associated with both physical and mental HRQoL among nonagenarians. Further studies are needed to explore the subsystems involved in this association, and whether improving muscle performance might improve global mental and physical quality of life in the most advanced age.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
Publication statusPublished - 2020


  • Geriatrics
  • Muscle Strenght
  • Quality of Life


Dive into the research topics of 'Muscle strength is related to mental and physical quality of life in the oldest old'. Together they form a unique fingerprint.

Cite this