Muscle histology vs MRI in Duchenne muscular dystrophy

M. Kinali; V. Arechavala-Gomeza; S. Cirak; A. Glover; M. Guglieri; L. Feng; K. G. Hollingsworth; D. Hunt; H. Jungbluth; H. P. Roper; R. M. Quinlivan; J. A. Gosalakkal; S. Jayawant; A. Nadeau; L. Hughes-Carre; A. Y. Manzur; Eugenio Maria Mercuri; J. E. Morgan; V. Straub; K. Bushby; C. Sewry; M. Rutherford; F. Muntoni

doi:10.1212/WNL.0b013e318208811f

Muscle histology vs MRI in Duchenne muscular dystrophy

M. Kinali
, V. Arechavala-Gomeza
, S. Cirak
, A. Glover
, M. Guglieri
, L. Feng
, K. G. Hollingsworth
, D. Hunt
, H. Jungbluth
, H. P. Roper
, R. M. Quinlivan
, J. A. Gosalakkal
, S. Jayawant
, A. Nadeau
, L. Hughes-Carre
, A. Y. Manzur
, Eugenio Maria Mercuri
, J. E. Morgan
, V. Straub
, K. Bushby

C. Sewry, M. Rutherford, F. Muntoni

University College London
Hammersmith Hospital
Newcastle University
St. Mary's Hospital
Evelina London Children's Healthcare
University Hospitals Birmingham NHS Foundation Trust
University Hospitals of Leicester
John Radcliffe Hospital
Departments of Paediatrics

Research output: Contribution to journal › Article

102 Citations (Scopus)

Abstract

There are currently no effective treatments to halt the muscle breakdown in Duchenne muscular dystrophy (DMD), although genetic-based clinical trials are being piloted. Most of these trials have as an endpoint the restoration of dystrophin in muscle fibers, hence requiring sufficiently well-preserved muscle of recruited patients. The choice of the muscles to be studied and the role of noninvasive methods to assess muscle preservation therefore require further evaluation.

Original language	English
Pages (from-to)	346-353
Number of pages	8
Journal	Neurology
Volume	76
DOIs	https://doi.org/10.1212/WNL.0b013e318208811f
Publication status	Published - 2011

Keywords

Adolescent
Child
Foot
Humans
Leg
Magnetic Resonance Imaging
Male
Muscle, Skeletal
Muscular Dystrophy, Duchenne

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10.1212/WNL.0b013e318208811f

Cite this

Kinali, M., Arechavala-Gomeza, V., Cirak, S., Glover, A., Guglieri, M., Feng, L., Hollingsworth, K. G., Hunt, D., Jungbluth, H., Roper, H. P., Quinlivan, R. M., Gosalakkal, J. A., Jayawant, S., Nadeau, A., Hughes-Carre, L., Manzur, A. Y., Mercuri, E. M., Morgan, J. E., Straub, V., ... Muntoni, F. (2011). Muscle histology vs MRI in Duchenne muscular dystrophy. Neurology, 76, 346-353. https://doi.org/10.1212/WNL.0b013e318208811f

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title = "Muscle histology vs MRI in Duchenne muscular dystrophy",

abstract = "There are currently no effective treatments to halt the muscle breakdown in Duchenne muscular dystrophy (DMD), although genetic-based clinical trials are being piloted. Most of these trials have as an endpoint the restoration of dystrophin in muscle fibers, hence requiring sufficiently well-preserved muscle of recruited patients. The choice of the muscles to be studied and the role of noninvasive methods to assess muscle preservation therefore require further evaluation.",

keywords = "Adolescent, Child, Foot, Humans, Leg, Magnetic Resonance Imaging, Male, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Adolescent, Child, Foot, Humans, Leg, Magnetic Resonance Imaging, Male, Muscle, Skeletal, Muscular Dystrophy, Duchenne",

author = "M. Kinali and V. Arechavala-Gomeza and S. Cirak and A. Glover and M. Guglieri and L. Feng and Hollingsworth, \{K. G.\} and D. Hunt and H. Jungbluth and Roper, \{H. P.\} and Quinlivan, \{R. M.\} and Gosalakkal, \{J. A.\} and S. Jayawant and A. Nadeau and L. Hughes-Carre and Manzur, \{A. Y.\} and Mercuri, \{Eugenio Maria\} and Morgan, \{J. E.\} and V. Straub and K. Bushby and C. Sewry and M. Rutherford and F. Muntoni",

year = "2011",

doi = "10.1212/WNL.0b013e318208811f",

language = "English",

volume = "76",

pages = "346--353",

journal = "Neurology",

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}

Kinali, M, Arechavala-Gomeza, V, Cirak, S, Glover, A, Guglieri, M, Feng, L, Hollingsworth, KG, Hunt, D, Jungbluth, H, Roper, HP, Quinlivan, RM, Gosalakkal, JA, Jayawant, S, Nadeau, A, Hughes-Carre, L, Manzur, AY, Mercuri, EM, Morgan, JE, Straub, V, Bushby, K, Sewry, C, Rutherford, M & Muntoni, F 2011, 'Muscle histology vs MRI in Duchenne muscular dystrophy', Neurology, vol. 76, pp. 346-353. https://doi.org/10.1212/WNL.0b013e318208811f

TY - JOUR

T1 - Muscle histology vs MRI in Duchenne muscular dystrophy

AU - Kinali, M.

AU - Arechavala-Gomeza, V.

AU - Cirak, S.

AU - Glover, A.

AU - Guglieri, M.

AU - Feng, L.

AU - Hollingsworth, K. G.

AU - Hunt, D.

AU - Jungbluth, H.

AU - Roper, H. P.

AU - Quinlivan, R. M.

AU - Gosalakkal, J. A.

AU - Jayawant, S.

AU - Nadeau, A.

AU - Hughes-Carre, L.

AU - Manzur, A. Y.

AU - Mercuri, Eugenio Maria

AU - Morgan, J. E.

AU - Straub, V.

AU - Bushby, K.

AU - Sewry, C.

AU - Rutherford, M.

AU - Muntoni, F.

PY - 2011

Y1 - 2011

N2 - There are currently no effective treatments to halt the muscle breakdown in Duchenne muscular dystrophy (DMD), although genetic-based clinical trials are being piloted. Most of these trials have as an endpoint the restoration of dystrophin in muscle fibers, hence requiring sufficiently well-preserved muscle of recruited patients. The choice of the muscles to be studied and the role of noninvasive methods to assess muscle preservation therefore require further evaluation.

AB - There are currently no effective treatments to halt the muscle breakdown in Duchenne muscular dystrophy (DMD), although genetic-based clinical trials are being piloted. Most of these trials have as an endpoint the restoration of dystrophin in muscle fibers, hence requiring sufficiently well-preserved muscle of recruited patients. The choice of the muscles to be studied and the role of noninvasive methods to assess muscle preservation therefore require further evaluation.

KW - Adolescent

KW - Child

KW - Foot

KW - Humans

KW - Leg

KW - Magnetic Resonance Imaging

KW - Male

KW - Muscle, Skeletal

KW - Muscular Dystrophy, Duchenne

KW - Adolescent

KW - Child

KW - Foot

KW - Humans

KW - Leg

KW - Magnetic Resonance Imaging

KW - Male

KW - Muscle, Skeletal

KW - Muscular Dystrophy, Duchenne

UR - http://hdl.handle.net/10807/6747

U2 - 10.1212/WNL.0b013e318208811f

DO - 10.1212/WNL.0b013e318208811f

M3 - Article

SN - 0028-3878

VL - 76

SP - 346

EP - 353

JO - Neurology

JF - Neurology

ER -

Muscle histology vs MRI in Duchenne muscular dystrophy

Abstract

Keywords

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