Multiple Sclerosis attacks triggered by hyperprolactinemia

Tommaso Tartaglione, Viviana Nociti, Giovanni Frisullo, Agata Katia Patanella, Raffaele Iorio, Anna Paola Batocchi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course
Original languageEnglish
Pages (from-to)407-409
Number of pages3
JournalJournal of Neuro-Oncology
Volume2010
Publication statusPublished - 2010

Keywords

  • multiple sclerosis
  • prolactin

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