Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes

Luca Laurenti, S Ferrero, D Capello, M Svaldi, M Boi, D Gatti, D Drandi, D Rossi, S Barbiero, B Mantoan, E Mantella, M Zanni, P Ghione, A Larocca, R Passera, F Bertoni, V Gattei, F Forconi, G Del Poeta, R MarascaS Cortelazzo, G Gaidano, A Palumbo, M Boccadoro, M. Ladetto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic drive.
Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalHaematologica
Volume97
DOIs
Publication statusPublished - 2012

Keywords

  • B-Lymphocytes
  • Complementarity Determining Regions
  • Data Mining
  • Databases, Nucleic Acid
  • Genes, Immunoglobulin Heavy Chain
  • Humans
  • Multigene Family
  • Multiple Myeloma
  • Myeloma Proteins
  • Sequence Analysis, DNA
  • Somatic Hypermutation, Immunoglobulin

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