TY - JOUR
T1 - MRI and Trouillas’ grading system of pituitary tumors: the usefulness of T2 signal intensity volumetric values
AU - Calandrelli, Rosalinda
AU - Pilato, Fabio
AU - D'Apolito, Gabriella
AU - Schiavetto, Stefano
AU - Gessi, Marco
AU - D'Alessandris, Quintino Giorgio
AU - Lauretti, Liverana
AU - Gaudino, Simona
PY - 2023
Y1 - 2023
N2 - PurposeTo classify pituitary macroadenomas according to the Trouillas' grading system; to compare this grading system with T2 values of volumetric signal intensity to determine T2 values able to predict the final grade.MethodsA total of 106 patients with macroadenomas were grouped according to the grading system score combining proliferation and invasiveness criteria of Trouillas' classification. Normalized volumetric signal intensity values were extracted from coronal T2-weighted images (nT2mean, nT2Max, nT2min) and were compared with the final grading score system.ResultsThirty-three patients were in grade 1a (non-invasive, non-proliferative tumors), 17 patients in grade 1b (non-invasive, proliferative tumors), 36 patients in grade 2a (invasive, non-proliferative tumors), and 20 patients in grade 2b (invasive, proliferative tumors). No patient was in grade 3 (metastatic tumors). nT2Max and nT2min were the best quantitative values to discriminate invasive from non-invasive grades; in invasive grades, nT2Max intensity values were higher, and nT2min intensity values were lower than in non-invasive grades.Receiver operating characteristic analysis of nT2 values showed that nT2min values had a better diagnostic performance than nT2Max values because they allowed differentiating with a moderate accuracy invasive tumors (2a or 2b grades) from both non-invasive proliferative tumors (1b) and non-invasive-non proliferative tumors (1a) (2a vs 1b: AUC(nT2min) = 0.78, 2b vs 1b: AUC(nT2min) = 0.72, 2a vs 1a: AUC(nT2min) = 0.72, 2b vs 1a AUC(nT2min) = 0.69).ConclusionVolumetric nT2Max and nT2min values of MRI might be practical and non-invasive markers for assessing tumor invasiveness although nT2 min signal intensity values have more effects in discriminating tumor's invasive behavior.
AB - PurposeTo classify pituitary macroadenomas according to the Trouillas' grading system; to compare this grading system with T2 values of volumetric signal intensity to determine T2 values able to predict the final grade.MethodsA total of 106 patients with macroadenomas were grouped according to the grading system score combining proliferation and invasiveness criteria of Trouillas' classification. Normalized volumetric signal intensity values were extracted from coronal T2-weighted images (nT2mean, nT2Max, nT2min) and were compared with the final grading score system.ResultsThirty-three patients were in grade 1a (non-invasive, non-proliferative tumors), 17 patients in grade 1b (non-invasive, proliferative tumors), 36 patients in grade 2a (invasive, non-proliferative tumors), and 20 patients in grade 2b (invasive, proliferative tumors). No patient was in grade 3 (metastatic tumors). nT2Max and nT2min were the best quantitative values to discriminate invasive from non-invasive grades; in invasive grades, nT2Max intensity values were higher, and nT2min intensity values were lower than in non-invasive grades.Receiver operating characteristic analysis of nT2 values showed that nT2min values had a better diagnostic performance than nT2Max values because they allowed differentiating with a moderate accuracy invasive tumors (2a or 2b grades) from both non-invasive proliferative tumors (1b) and non-invasive-non proliferative tumors (1a) (2a vs 1b: AUC(nT2min) = 0.78, 2b vs 1b: AUC(nT2min) = 0.72, 2a vs 1a: AUC(nT2min) = 0.72, 2b vs 1a AUC(nT2min) = 0.69).ConclusionVolumetric nT2Max and nT2min values of MRI might be practical and non-invasive markers for assessing tumor invasiveness although nT2 min signal intensity values have more effects in discriminating tumor's invasive behavior.
KW - Clinic-pathological classification by Trouillas
KW - nT2 volumetric values
KW - Macroadenomas
KW - Invasive and non-invasive grades
KW - Clinic-pathological classification by Trouillas
KW - nT2 volumetric values
KW - Macroadenomas
KW - Invasive and non-invasive grades
UR - http://hdl.handle.net/10807/271359
U2 - 10.1007/s00234-023-03162-5
DO - 10.1007/s00234-023-03162-5
M3 - Article
SN - 0028-3940
VL - 65
SP - 1567
EP - 1578
JO - Neuroradiology
JF - Neuroradiology
ER -