Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

Paolo Bartolomeo, Gianfranco Dalla Barba, Ac Bachoud Lévi, P Rémy, Jp Nguyen, P Brugières, Jp Lefaucheur, C Bourdet, S Baudic, V Gaura, P Maison, B Haddad, Mf Boissé, T Grandmougin, R Jény, Jd Degos, F Lisovoski, Am Ergis, E Pailhous, Pierre CesaroP Hantraye, M. Peschanski

Research output: Contribution to journalArticle

379 Citations (Scopus)

Abstract

Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.
Original languageEnglish
Pages (from-to)1975-1979
Number of pages5
JournalThe Lancet
Volume356
Publication statusPublished - 2000

Keywords

  • Brain
  • Brain Tissue Transplantation
  • Cognition
  • Corpus Striatum
  • Evoked Potentials, Somatosensory
  • Follow-Up Studies
  • Humans
  • Huntington Disease
  • Magnetic Resonance Imaging
  • Motor Activity
  • Neuropsychological Tests
  • Tomography, Emission-Computed
  • Treatment Outcome

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