Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.
Original languageEnglish
Pages (from-to)1-36
Number of pages36
Publication statusPublished - 2018


  • BRAF mutation
  • immunocytochemistry
  • molecular testing
  • plump cells
  • thyroid malignancies
  • thyroid nodules


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