Morphological and Functional Abnormalities in the Inner Retina of the rd/rd mouse.

Benedetto Falsini, Vittorio Porciatti, Enrica Strettoi, Vincenzo Pignatelli, Chiara Rossi

Research output: Contribution to journalArticlepeer-review

240 Citations (Scopus)

Abstract

We investigated the effects of photoreceptor degeneration on the anatomy and physiology of inner retinal neurons in a mouse model of retinitis pigmentosa, the retinal degeneration (rd) mutant mouse. Although there is a general assumption that the inner retinal cells do not suffer from photoreceptor death, we confirmed major changes both accompanying and after this process. Changes include sprouting of horizontal cells, lack of development of dendrites of rod bipolar cells, and progressive atrophy of dendrites in cone bipolar cells. Electrophysiological recordings demonstrate a selective impairment of second-order neurons that is not predictable on the basis of a pure photoreceptor dysfunction. Our data point out the necessity to prove integrity of the inner retina before attempting restoring visual function through photoreceptor intervention. This is even more important when considering that although intervention can be performed before the onset of any symptoms in animals carrying inherited retinopathies, this is obviously not true for human subjects.
Original languageEnglish
Pages (from-to)5492-5504
Number of pages13
JournalJ Neurosci. 2002 Jul 1;22(13):5492-5504. IF: 8.502
Publication statusPublished - 2002

Keywords

  • Electroretinography
  • Histology
  • Retinal Degenerations

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