Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Jane Willoughby; Vivette Glover; Merton Sandler; Alberto Albanese; Peter Jenner; C.David Marsden

doi:10.1016/0304-3940(88)90794-X

Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Jane Willoughby
, Vivette Glover
, Merton Sandler
, Alberto Albanese
, Peter Jenner
, C.David Marsden

Imperial College Healthcare NHS Trust
Medical Research Council

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

Original language	English
Pages (from-to)	100-106
Number of pages	7
Journal	Neuroscience Letters
Volume	90
DOIs	https://doi.org/10.1016/0304-3940(88)90794-X
Publication status	Published - 1988

Keywords

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain
Callitrichinae
Female
Histocytochemistry
Monoamine Oxidase
Pyridines
Rats

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10.1016/0304-3940(88)90794-X

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title = "Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity",

abstract = "This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.",

keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Brain, Callitrichinae, Female, Histocytochemistry, Monoamine Oxidase, Pyridines, Rats, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Brain, Callitrichinae, Female, Histocytochemistry, Monoamine Oxidase, Pyridines, Rats",

author = "Jane Willoughby and Vivette Glover and Merton Sandler and Alberto Albanese and Peter Jenner and C.David Marsden",

year = "1988",

doi = "10.1016/0304-3940(88)90794-X",

language = "English",

volume = "90",

pages = "100--106",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

AU - Willoughby, Jane

AU - Glover, Vivette

AU - Sandler, Merton

AU - Albanese, Alberto

AU - Jenner, Peter

AU - Marsden, C.David

PY - 1988

Y1 - 1988

N2 - This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

AB - This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

KW - Animals

KW - Brain

KW - Callitrichinae

KW - Female

KW - Histocytochemistry

KW - Monoamine Oxidase

KW - Pyridines

KW - Rats

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

KW - Animals

KW - Brain

KW - Callitrichinae

KW - Female

KW - Histocytochemistry

KW - Monoamine Oxidase

KW - Pyridines

KW - Rats

UR - http://hdl.handle.net/10807/25200

U2 - 10.1016/0304-3940(88)90794-X

DO - 10.1016/0304-3940(88)90794-X

M3 - Article

SN - 0304-3940

VL - 90

SP - 100

EP - 106

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Abstract

Keywords

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