Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling

Anna Rita Fetoni, Fabiola Paciello, Gaetano Paludetti, Daniele Mezzogori, Rolando Rolesi, Sara Letizia Maria Eramo, Diana Troiani

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

In oncology, an emerging paradigm emphasises molecularly targeted approaches for cancer prevention and therapy and the use of adjuvant chemotherapeutics to overcome cisplatin limitations. Owing to their safe use, some polyphenols, such as curcumin, modulate important pathways or molecular targets in cancers. This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.
Original languageEnglish
Pages (from-to)1434-1444
Number of pages11
JournalBritish Journal of Cancer
Volume113
DOIs
Publication statusPublished - 2015

Keywords

  • cisplatin
  • ototoxicity

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