Molecular signaling blockade as a new approach to inhibit leukocyte-endothelial interactions for inflammatory bowel disease treatment.

Franco Scaldaferri, Antonio Gasbarrini, Silvio Danese, Carmen Correale

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from intestinal biopsies of active IBD patients. In vitro experiments demonstrated that MAPK activation on intestinal endothelial cells and fibroblasts are responsible for the production of certain chemokines, increased leukocyte adhesion and transmigration. Specific local inhibition of MAPK activity on endothelial cells and fibroblasts may provide a new mechanism to control mucosal inflammation and leukocyte recruitment into the intestine of active IBD patients.
Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalCELL ADHESION & MIGRATION
Publication statusPublished - 2009

Keywords

  • Molecular signaling blockade

Fingerprint

Dive into the research topics of 'Molecular signaling blockade as a new approach to inhibit leukocyte-endothelial interactions for inflammatory bowel disease treatment.'. Together they form a unique fingerprint.

Cite this