Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment

Antonio Ruggiero, Maurizio Martini, Palma Maurizi, Daniela Rizzo, Valentina Rizzo, Riccardo Riccardi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biology is starting to impact drug development towards targeted therapies. The identification of agents directed against molecular targets aims at going beyond the traditional therapeutic approach in order to develop a personalized therapy and improve the outcome of pediatric high-grade gliomas. In this paper, we critically review the literature regarding the genetic abnormalities implicated in the pathogenesis of pediatric malignant gliomas and the current development of molecularly targeted therapies. In particular, we analyse the impact of molecular biology on the prognosis and treatment of pediatric high-grade glioma, comparing it to that of adult gliomas.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Keywords

  • Adolescent
  • Adult
  • Biochemistry, Genetics and Molecular Biology (all)
  • Biomarkers, Tumor
  • Brain Neoplasms
  • Child
  • Child, Preschool
  • Female
  • Glioma
  • Humans
  • Immunology and Microbiology (all)
  • Infant
  • Male
  • Neoplasm Proteins

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