Molecular basis of COVID-19 relationships in different species: a one health perspective

Bruno Tilocca; Alessio Soggiu; Vincenzo Musella; Domenico Britti; Maurizio Sanguinetti; Andrea Urbani; Paola Roncada

doi:10.1016/j.micinf.2020.03.002

Molecular basis of COVID-19 relationships in different species: a one health perspective

Bruno Tilocca
, Alessio Soggiu
, Vincenzo Musella
, Domenico Britti
, Maurizio Sanguinetti
, Andrea Urbani
, Paola Roncada

Magna Græcia University
University of Milan

Research output: Contribution to journal › Article

Abstract

Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.

Original language	English
Pages (from-to)	218-220
Number of pages	3
Journal	Microbes and Infection
Volume	22
DOIs	https://doi.org/10.1016/j.micinf.2020.03.002
Publication status	Published - 2020

Keywords

ANTIBODIES
CORONAVIRUS
INFECTION

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10.1016/j.micinf.2020.03.002

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title = "Molecular basis of COVID-19 relationships in different species: a one health perspective",

abstract = "Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of {\textquotedblleft}unconventional{\textquotedblright} biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.",

keywords = "ANTIBODIES, CORONAVIRUS, INFECTION, ANTIBODIES, CORONAVIRUS, INFECTION",

author = "Bruno Tilocca and Alessio Soggiu and Vincenzo Musella and Domenico Britti and Maurizio Sanguinetti and Andrea Urbani and Paola Roncada",

year = "2020",

doi = "10.1016/j.micinf.2020.03.002",

language = "English",

volume = "22",

pages = "218--220",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson s.r.l.",

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TY - JOUR

T1 - Molecular basis of COVID-19 relationships in different species: a one health perspective

AU - Tilocca, Bruno

AU - Soggiu, Alessio

AU - Musella, Vincenzo

AU - Britti, Domenico

AU - Sanguinetti, Maurizio

AU - Urbani, Andrea

AU - Roncada, Paola

PY - 2020

Y1 - 2020

N2 - Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.

AB - Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.

KW - ANTIBODIES

KW - CORONAVIRUS

KW - INFECTION

KW - ANTIBODIES

KW - CORONAVIRUS

KW - INFECTION

UR - http://hdl.handle.net/10807/234014

U2 - 10.1016/j.micinf.2020.03.002

DO - 10.1016/j.micinf.2020.03.002

M3 - Article

SN - 1286-4579

VL - 22

SP - 218

EP - 220

JO - Microbes and Infection

JF - Microbes and Infection

ER -

Molecular basis of COVID-19 relationships in different species: a one health perspective

Abstract

Keywords

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