Modeling sarcopenia: a geriatric disease of skeletal muscle tissue

Giulia Giantesio; Alfredo Marzocchi; Alessandro Musesti

Modeling sarcopenia: a geriatric disease of skeletal muscle tissue

Giulia Giantesio^*, Alfredo Marzocchi, Alessandro Musesti

^*Corresponding author

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We propose a continuum model of skeletal muscle tissue with a reduced performance due to ageing. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient.

Original language	English
Title of host publication	5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017
Pages	400-402
Number of pages	3
Publication status	Published - 2017
Event	5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017 - Pittsburgh Duration: 9 Apr 2017 → 12 Apr 2017

Conference

Conference	5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017
City	Pittsburgh
Period	9/4/17 → 12/4/17

Keywords

sarcopenia, active strain, hyperelasticity, damage

Cite this

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title = "Modeling sarcopenia: a geriatric disease of skeletal muscle tissue",

abstract = "We propose a continuum model of skeletal muscle tissue with a reduced performance due to ageing. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient.",

keywords = "sarcopenia, active strain, hyperelasticity, damage, sarcopenia, active strain, hyperelasticity, damage",

author = "Giulia Giantesio and Alfredo Marzocchi and Alessandro Musesti",

year = "2017",

language = "English",

pages = "400--402",

booktitle = "5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017",

note = "5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017 ; Conference date: 09-04-2017 Through 12-04-2017",

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TY - GEN

T1 - Modeling sarcopenia: a geriatric disease of skeletal muscle tissue

AU - Giantesio, Giulia

AU - Marzocchi, Alfredo

AU - Musesti, Alessandro

PY - 2017

Y1 - 2017

N2 - We propose a continuum model of skeletal muscle tissue with a reduced performance due to ageing. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient.

AB - We propose a continuum model of skeletal muscle tissue with a reduced performance due to ageing. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient.

KW - sarcopenia, active strain, hyperelasticity, damage

UR - http://hdl.handle.net/10807/120505

M3 - Conference contribution

SP - 400

EP - 402

BT - 5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017

T2 - 5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017

Y2 - 9 April 2017 through 12 April 2017

ER -

Modeling sarcopenia: a geriatric disease of skeletal muscle tissue

Abstract

Conference

Keywords

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