MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Cristina Grippaudo, Carla Loreto, Veronica Filetti, Luis Eduardo Almeida, Giusy Rita Maria La Rosa, Rosalia Leonardi, Antonino Lo Giudice

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.
Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalEuropean Journal of Histochemistry
Volume2020
Publication statusPublished - 2020

Keywords

  • MMP-7
  • MMP-9

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