Abstract
Aging, a highly complex and multifactorial process, can be framed as a physiological mismatch resulting from decreasing resilience and increasing levels of damage generation and accumulation. Intrinsic drivers of human aging have been discovered and attributed a role in the pathogenesis of frailty and sarcopenia. Mitochondrial function and signaling are in the spotlight as relevant mechanisms of aging. Declines in functional health are a frequent trait of old age and a major factor limiting independence in late life. Measures of physical performance are also metrics of aging as they can predict incident disability and other health-related negative events. The integration of measures of mitochondrial biology and other hallmarks of aging allows a comprehensive appraisal of the events underlying the development and progression of frailty and sarcopenia.
| Original language | English |
|---|---|
| Title of host publication | Frailty |
| Publisher | Springer Nature Switzerland AG |
| Pages | 103-107 |
| Number of pages | 5 |
| ISBN (Print) | 978-3-031-57360-6 |
| DOIs | |
| Publication status | Published - 2024 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- General Medicine
Keywords
- Apoptosis
- Mitochondrial quality control
- Mitophagy
- Muscle wasting
- Oxidative stress
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