Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View

Marta Gonzalez-Freire; Stephen D. Anton; Emanuele Marzetti; Christiaan Leeuwenburgh

doi:10.1007/978-3-031-57361-3_14

Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View

Marta Gonzalez-Freire, Stephen D. Anton, Emanuele Marzetti, Christiaan Leeuwenburgh

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Aging, a highly complex and multifactorial process, can be framed as a physiological mismatch resulting from decreasing resilience and increasing levels of damage generation and accumulation. Intrinsic drivers of human aging have been discovered and attributed a role in the pathogenesis of frailty and sarcopenia. Mitochondrial function and signaling are in the spotlight as relevant mechanisms of aging. Declines in functional health are a frequent trait of old age and a major factor limiting independence in late life. Measures of physical performance are also metrics of aging as they can predict incident disability and other health-related negative events. The integration of measures of mitochondrial biology and other hallmarks of aging allows a comprehensive appraisal of the events underlying the development and progression of frailty and sarcopenia.

Original language	English
Title of host publication	Frailty
Editors	Olga Theou Jorge G. Ruiz
Pages	103-107
Number of pages	5
DOIs	https://doi.org/10.1007/978-3-031-57361-3_14
Publication status	Published - 2024

Keywords

Apoptosis
Mitochondrial quality control
Mitophagy
Muscle wasting
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-031-57361-3_14

Cite this

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abstract = "Aging, a highly complex and multifactorial process, can be framed as a physiological mismatch resulting from decreasing resilience and increasing levels of damage generation and accumulation. Intrinsic drivers of human aging have been discovered and attributed a role in the pathogenesis of frailty and sarcopenia. Mitochondrial function and signaling are in the spotlight as relevant mechanisms of aging. Declines in functional health are a frequent trait of old age and a major factor limiting independence in late life. Measures of physical performance are also metrics of aging as they can predict incident disability and other health-related negative events. The integration of measures of mitochondrial biology and other hallmarks of aging allows a comprehensive appraisal of the events underlying the development and progression of frailty and sarcopenia.",

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T1 - Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View

AU - Gonzalez-Freire, Marta

AU - Anton, Stephen D.

AU - Marzetti, Emanuele

AU - Leeuwenburgh, Christiaan

PY - 2024

Y1 - 2024

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AB - Aging, a highly complex and multifactorial process, can be framed as a physiological mismatch resulting from decreasing resilience and increasing levels of damage generation and accumulation. Intrinsic drivers of human aging have been discovered and attributed a role in the pathogenesis of frailty and sarcopenia. Mitochondrial function and signaling are in the spotlight as relevant mechanisms of aging. Declines in functional health are a frequent trait of old age and a major factor limiting independence in late life. Measures of physical performance are also metrics of aging as they can predict incident disability and other health-related negative events. The integration of measures of mitochondrial biology and other hallmarks of aging allows a comprehensive appraisal of the events underlying the development and progression of frailty and sarcopenia.

KW - Apoptosis

KW - Mitochondrial quality control

KW - Mitophagy

KW - Muscle wasting

KW - Oxidative stress

KW - Apoptosis

KW - Mitochondrial quality control

KW - Mitophagy

KW - Muscle wasting

KW - Oxidative stress

UR - http://hdl.handle.net/10807/278897

U2 - 10.1007/978-3-031-57361-3_14

DO - 10.1007/978-3-031-57361-3_14

M3 - Chapter

SN - 978-3-031-57360-6

SP - 103

EP - 107

BT - Frailty

A2 - Jorge G. Ruiz, Olga Theou

ER -

Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View

Abstract

Keywords

UN SDGs

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