Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Francesca Addante, Antonio D’Amati, Angela Santoro*, Giuseppe Angelico, Frediano Inzani, Damiano Arciuolo, Antonio Travaglino, Antonio Raffone, Nicoletta D'Alessandris, Giulia Scaglione, Michele Valente, Giordana Tinnirello, Stefania Sfregola, Belen Padial Urtueta, Angelo Piermattei, Federica Cianfrini, Antonino Mulè, Emma Bragantini, Gian Franco Zannoni

*Corresponding author

Research output: Contribution to journalArticle

Abstract

Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.
Original languageEnglish
Pages (from-to)1056-1062
Number of pages7
JournalInternational Journal of Molecular Sciences
Volume25
DOIs
Publication statusPublished - 2024

Keywords

  • ENDOMETRIAL CANCER

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