TY - JOUR
T1 - Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications
AU - Addante, Francesca
AU - D’Amati, Antonio
AU - Santoro, Angela
AU - Angelico, Giuseppe
AU - Inzani, Frediano
AU - Arciuolo, Damiano
AU - Travaglino, Antonio
AU - Raffone, Antonio
AU - D'Alessandris, Nicoletta
AU - Scaglione, Giulia
AU - Valente, Michele
AU - Tinnirello, Giordana
AU - Sfregola, Stefania
AU - Padial Urtueta, Belen
AU - Piermattei, Angelo
AU - Cianfrini, Federica
AU - Mulè, Antonino
AU - Bragantini, Emma
AU - Zannoni, Gian Franco
PY - 2024
Y1 - 2024
N2 - Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.
AB - Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.
KW - ENDOMETRIAL CANCER
KW - ENDOMETRIAL CANCER
UR - http://hdl.handle.net/10807/271422
U2 - 10.3390/ijms25021056
DO - 10.3390/ijms25021056
M3 - Article
SN - 1422-0067
VL - 25
SP - 1056
EP - 1062
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -