MiRNA landscape in primary tumors and matched metastases in gastrointestinal stromal tumors

Riccardo Ricci, Qianqian Zhang, Antonio Graziosi, Gloria Ravegnini, Cèsar Serrano, Irene Terrenato, Agnese Graziosi, Giorgia Valori, Stefania Landolfi, Patrizia Hrelia, Sabrina Angelini

Research output: Contribution to journalArticlepeer-review

Abstract

Gastrointestinal stromal tumor management is extremely challenging, particularly the metastatic disease. The underlying mechanism in metastasis spread remains largely unknown. We aimed to characterize miRNAs involved in the metastatic process in gastrointestinal stromal tumor. Material & methods: Eight primary tumors and 18 synchronous metastases were analyzed through miRNA Taqman arrays or assays. Results: miRNAs profiles revealed similar expression in primary site and metastases. Pair-wise correlation coefficient between primary tumor and metastases was significant for each patient (p < 0.0001 for all profiled patients). Conclusion: Our study, the largest including primary tumors and metastases so far performed, highlighted perpetuation of miRNAs features in metastatic lesions and that the primary origin appears to be the main determinant of the metastases miRNA profile.
Original languageEnglish
Pages (from-to)369-377
Number of pages9
JournalEpigenomics
Volume13
DOIs
Publication statusPublished - 2021

Keywords

  • GIST
  • metastases
  • primary tumor
  • miRNA
  • metastatic lesion

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