MicroRNAs and prostate cancer

Ruggero De Maria Marchiano, Valeria Coppola, Désirée Bonci

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNAderegulation in prostate cancer disease, underlining present limits and future perspectives. © 2010 Society for Endocrinology.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalEndocrine-Related Cancer
Volume17
DOIs
Publication statusPublished - 2010

Keywords

  • Adenocarcinoma
  • Androgens
  • Cancer Research
  • Cell Transformation, Neoplastic
  • Disease Progression
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Humans
  • Male
  • MicroRNAs
  • Neoplasm Invasiveness
  • Neoplasm Proteins
  • Neoplasms, Hormone-Dependent
  • Oncology
  • Prognosis
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins c-myc
  • RNA, Neoplasm

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