TY - JOUR
T1 - MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
AU - Alivernini, Stefano
AU - Gremese, Elisa
AU - Mcsharry, Charles
AU - Tolusso, Barbara
AU - Ferraccioli, Gianfranco
AU - Mcinnes, Iain B.
AU - Kurowska-Stolarska, Mariola
PY - 2018
Y1 - 2018
N2 - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to
a changing environment by modulating the cell transcriptome. miR-155 is a
multifunctional miRNA enriched in cells of the immune system and is indispensable
for the immune response. However, when deregulated, miR-155 contributes to the
development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein,
we review the evidence for the pathogenic role of miR-155 in driving aberrant
activation of the immune system in rheumatoid arthritis, and its potential as a
disease biomarker and therapeutic target.
AB - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to
a changing environment by modulating the cell transcriptome. miR-155 is a
multifunctional miRNA enriched in cells of the immune system and is indispensable
for the immune response. However, when deregulated, miR-155 contributes to the
development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein,
we review the evidence for the pathogenic role of miR-155 in driving aberrant
activation of the immune system in rheumatoid arthritis, and its potential as a
disease biomarker and therapeutic target.
KW - microRNA
KW - microRNA
UR - http://hdl.handle.net/10807/114714
U2 - 10.3389/fimmu.2017.01932
DO - 10.3389/fimmu.2017.01932
M3 - Article
SN - 1664-3224
SP - 1932-N/A
JO - Frontiers in Immunology
JF - Frontiers in Immunology
ER -
