Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Remi A. Kessler; Tomas Garzon-Muvdi; Wuyang Yang; Jon Weingart; Alessandro Olivi; Judy Huang; Henry Brem; Michael Lim

doi:10.1016/j.wneu.2017.01.070

Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Remi A. Kessler, Tomas Garzon-Muvdi, Wuyang Yang, Jon Weingart, Alessandro Olivi, Judy Huang, Henry Brem, Michael Lim

Johns Hopkins University

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

Original language	English
Pages (from-to)	47-56
Number of pages	10
Journal	World Neurosurgery
Volume	101
DOIs	https://doi.org/10.1016/j.wneu.2017.01.070
Publication status	Published - 2017

Keywords

Anaplastic
Atypical
Meningioma
Metastasis
Resection

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10.1016/j.wneu.2017.01.070

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title = "Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature",

abstract = "BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.",

keywords = "Anaplastic, Atypical, Meningioma, Metastasis, Resection, Anaplastic, Atypical, Meningioma, Metastasis, Resection",

author = "Kessler, {Remi A.} and Tomas Garzon-Muvdi and Wuyang Yang and Jon Weingart and Alessandro Olivi and Judy Huang and Henry Brem and Michael Lim",

year = "2017",

doi = "10.1016/j.wneu.2017.01.070",

language = "English",

volume = "101",

pages = "47--56",

journal = "World Neurosurgery",

issn = "1878-8750",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

AU - Kessler, Remi A.

AU - Garzon-Muvdi, Tomas

AU - Yang, Wuyang

AU - Weingart, Jon

AU - Olivi, Alessandro

AU - Huang, Judy

AU - Brem, Henry

AU - Lim, Michael

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

AB - BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

KW - Anaplastic

KW - Atypical

KW - Meningioma

KW - Metastasis

KW - Resection

KW - Anaplastic

KW - Atypical

KW - Meningioma

KW - Metastasis

KW - Resection

UR - http://hdl.handle.net/10807/172161

U2 - 10.1016/j.wneu.2017.01.070

DO - 10.1016/j.wneu.2017.01.070

M3 - Article

SN - 1878-8750

VL - 101

SP - 47

EP - 56

JO - World Neurosurgery

JF - World Neurosurgery

ER -

Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Abstract

Keywords

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