Mediterranean diet and NAFLD: What we know and questions that still need to be answered

Maria Corina Plaz Torres, Alessio Aghemo, Ana Lleo, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Luca Miele, Edoardo G. Giannini

Research output: Contribution to journalArticle


Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is expected to become the leading cause of end-stage liver disease worldwide over the next few decades. In fact, NAFLD encompasses different clinical scenarios, from the simple accumulation of fat (steatosis) to steatohepatitis (NASH), NASH-cirrhosis, and cirrhosis complications. In this context, it is fundamental to pursue strategies aimed at both preventing the disease and reducing the progression of liver fibrosis once liver damage is already initiated. As of today, no pharmacological treatment has been approved for NAFLD/NASH, and the only recommended treatment of proven efficacy are life-style modifications, including diet and physical exercise pointing at weight loss of 5%–7%. Different dietetic approaches have been proposed in this setting, and in this review, we will discuss the evidence regarding the efficacy of the Mediterranean Diet as a treatment for NAFLD. In particular, we will report the effects on liver-related outcomes.
Original languageEnglish
Pages (from-to)2971-N/A
Publication statusPublished - 2019


  • Adipose Tissue
  • Adiposity
  • Chronic liver disease
  • Diet
  • Diet, Mediterranean
  • End Stage Liver Disease
  • Evidence-Based Medicine
  • Exercise
  • Humans
  • Life Style
  • Lifestyle intervention
  • Liver
  • Non-alcoholic Fatty Liver Disease
  • Nonalcoholic steatohepatitis
  • Outcome
  • Treatment Outcome
  • Weight Loss


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