Abstract
Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene.
| Original language | English |
|---|---|
| Pages (from-to) | 81-81 |
| Number of pages | 1 |
| Journal | BMC Medical Genetics |
| Volume | 13 |
| Issue number | Settembre |
| DOIs | |
| Publication status | Published - 2012 |
All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
Keywords
- Adult
- Base Sequence
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Melanocortin
- Melanoma
- Monozygotic
- Neoplasm Invasiveness
- Receptor
- Skin Neoplasms
- Twins
- Type 1
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