MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair

Ketty Peris, C Pellegrini, Mc Fargnoli, M Suppa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene.
Original languageEnglish
Pages (from-to)81-81
Number of pages1
JournalBMC Medical Genetics
Volume13
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Base Sequence
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Humans
  • Melanoma
  • Neoplasm Invasiveness
  • Receptor, Melanocortin, Type 1
  • Skin Neoplasms
  • Twins, Monozygotic

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