Management of adrenocortical carcinoma: A consensus statement of the Italian Society of Endocrinology (SIE)

Silvia Della Casa, A. Stigliano, I. Chiodini, R. Giordano, A. Faggiano, L. Canu, P. Loli, M. Luconi, F. Mantero, M. Terzolo

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

1. Monotherapy with mitotane is recommended in patients after incomplete surgical resection or in patients not fit for surgery or chemotherapy 1 ⊕⊕OO. 2. Monotherapy with mitotane may be recommended in advanced ACC with involvement of few organs and low-grade mitotic index, particularly when RFS after removal of the primary tumor has been longer than 12 months 1 ⊕OOOO. 3. The chemotherapeutic regimen EDP in combination with mitotane is recommended in most patients with advanced or metastatic ACC 1 ⊕⊕⊕⊕. 4. There are insufficient data to recommend a particular targeted therapy in patients with advanced ACC beyond ongoing clinical trials.
Original languageEnglish
Pages (from-to)103-121
Number of pages19
JournalJournal of Endocrinological Investigation
Volume39
DOIs
Publication statusPublished - 2016

Keywords

  • Adjuvant treatment
  • Adrenal Cortex Neoplasms
  • Adrenocortical Carcinoma
  • Adrenocortical carcinoma
  • Biopsy, Fine-Needle
  • Consensus
  • Diagnostic Imaging
  • Diagnostic Techniques, Endocrine
  • Hormones
  • Humans
  • Italy
  • Magnetic Resonance Imaging
  • Mitotane
  • Overall survival
  • Positron-Emission Tomography
  • Prognostic factors
  • Recurrence-free survival
  • Tomography, X-Ray Computed

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