Malignant peritoneal mesothelioma in a woman with bilateral ovarian serous borderline tumour: Potential interactions between the two diseases

Gian Franco Zannoni, Lorena Losi, Laura Botticelli, Gianluca Taccagni, Ernesto Longinotti, Cesare Lancellotti, Letizia Scurani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of a 59-year-old woman with peritoneal malignant mesothelioma and no previous exposure to asbestos with a diagnosis of bilateral ovarian serous borderline tumour with peritoneal implants one year before. We discuss the histopathological and immunohistochemical findings to explain possible and potential interactions between the two diseases. To our knowledge, the association of both serous borderline ovarian tumour and malignant peritoneal mesothelioma has never been described before in the same woman and in such a tight temporal connection. This finding raises numerous issues about the origin of the two tumours and further biomolecular studies are needed to fully understand the carcinogenetic process. From a clinical point of view, this case report can be useful to gynaecologists because it leads to recommend a careful examination of the peritoneal cavity during a surgical resection of borderline serous tumour. Moreover, it may suggest performing a close follow-up associated with a careful surveillance of the patient, especially in the case of micropapillary pattern, to oncologists. A complete clinical approach could help to detect sooner possible relapses or other metachronous malignancies.
Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalGYNECOLOGIC ONCOLOGY REPORT
Volume24
DOIs
Publication statusPublished - 2018

Keywords

  • Calretinin
  • Immunohistochemistry
  • Malignant peritoneal mesothelioma
  • Obstetrics and Gynecology
  • Oncology
  • Ovary
  • Peritoneal implants
  • Serous borderline tumour

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