MALATTIE PREVENIBILI CON VACCINAZIONE: VALUTAZIONE DELLA RISPOSTA IMMUNITARIA NEGLI STUDENTI UNIVERSITARI

[Autom. eng. transl.] Introduction. During his university career, he Faculty of Nursing students are exposed to several risk factors for the activity carried out in the practical training hospital, in particular if referring to biological risk. It is, therefore, important during surveillance healthcare pursuant to Legislative Decree 81/08, the evaluation of the response individual antibody for infectious diseases for during which mandatory vaccination is required childhood and which may be relevant in terms of risk of contagion and transmission for the student himself as well as for healthcare personnel and patients (Hepatitis B, Measles, Mumps, Rubella and Chickenpox). Goals. The objective of this study is to investigate the seroprevalence characteristics of antibodies IgG anti-HBsAg, anti-Measles, anti-Mumps, anti- Rubella and anti-chickenpox, in students of the Faculty of nursing of a “Teaching Hospital” in Rome. The analysis it also includes the descriptive study of demographic factors of the observed sample. Materials and methods. An observational study was carried out cross-sectional on 357 students of the Faculty of nurses, subjected to a preventive surveillance visit healthcare due to potential biological risk. Was evaluated the immune response to viruses in relation to reference range: Hepatitis B (positive ≥10 mIU/ml, negative <10 mIU/ml), Measles (positive ≥150 mIU/ml, negative <150 mIU/ml), Mumps (positive ≥230 AU/ml, negative <230 AU/ml), Rubella (positive ≥10 IU/ml, negative <10 IU/ml), Chickenpox (positive ≥50 mIU/ml, negative <50 mIU/ml). An analysis was then performed with STATA 17 software descriptive statistics of qualitative and quantitative variables taken into consideration and a bivariate analysis to study the association between vaccination coverage and relevant variables. Results. The observed sample consists of 357 students, mean age 21.2 (SD 4.1), of which 67 (18.8%) males and 290 (81.2%) females. From the analyzed data it is it emerged that 44.0% of students proved to be immunized against HBV, 86.4% against Measles, 86.7% against Mumps, 94.7% against Rubella and, finally, 94.9% against chickenpox. From bivariate analysis of the sample it emerged that the differences in antibody coverage they are not statistically significant across gender male and female for no virus caught in examination while they are for HBV and Rubella, in relation to the different age groups (p<0.001). From the assessment carried out it turned out that the majority of the population investigated presented an adequate antibody titer against Measles, Mumps, Rubella and Chickenpox, while lower to the desired towards HBV. Therefore, it was necessary proceed, on a voluntary basis as a recommended action, to the administration of booster doses of HBV vaccine for students with antibody titer insufficient, in the absence of contraindications to vaccination itself. Conclusions. In our sample, vaccination coverage towards Hepatitis B was not adequate to prevent any biological risks connected to the activities carried out in the department. Therefore, in terms of occupational prevention, control of vaccination coverage in students and staff healthcare exposed to biological risk due to the aforementioned diseases, is confirmed to be a fundamental tool importance during the health surveillance visit, also with a view to protecting increasingly frequent movements international student exchanges which sometimes occur in areas where hepatitis B is endemic. Bibliography 1) Amantea C, et al. Medical Liability of the Vaccinating Doctor: Comparing Policies in European Union Countries during the COVID-19 Pandemic. Int J Environ Res Public Health. 2