Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study

Giovanna Mantini; Valeria Valentini; Bruno Meduri; Stefano Margaritora; Marinella Balducci; F Micciché; Luigia Nardone; Fiorenza De Rose; Alfredo Cesario; Anna Rita Larici; F Maggi; Maria Lucia Calcagni; Pierluigi Granone

doi:10.1016/j.radonc.2012.09.006

Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study

Giovanna Mantini
, Valeria Valentini
, Bruno Meduri^*
, Stefano Margaritora
, Marinella Balducci
, F Micciché
, Luigia Nardone
, Fiorenza De Rose
, Alfredo Cesario
, Anna Rita Larici
, F Maggi
, Maria Lucia Calcagni
, Pierluigi Granone

^*Corresponding author

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

Low-dose radiotherapy (LDR) (<50 cGy) induces enhanced cell killing in vitro via the hyper-radiation sensitivity phenomenon. Aim of this study was to evaluate the safety and efficacy of a palliative regimen combining pemetrexed and LDR (as a chemopotentiator) on patients affected by recurrent non-small-cell lung cancer (NSCLC).

Original language	English
Pages (from-to)	161-166
Number of pages	6
Journal	Radiotherapy and Oncology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2012.09.006
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Radiology Nuclear Medicine and imaging

Keywords

nsclc

Access to Document

10.1016/j.radonc.2012.09.006

Cite this

Mantini, G., Valentini, V., Meduri, B., Margaritora, S., Balducci, M., Micciché, F., Nardone, L., De Rose, F., Cesario, A., Larici, A. R., Maggi, F., Calcagni, M. L., & Granone, P. (2012). Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study. Radiotherapy and Oncology, 105(2), 161-166. https://doi.org/10.1016/j.radonc.2012.09.006

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abstract = "Low-dose radiotherapy (LDR) (<50 cGy) induces enhanced cell killing in vitro via the hyper-radiation sensitivity phenomenon. Aim of this study was to evaluate the safety and efficacy of a palliative regimen combining pemetrexed and LDR (as a chemopotentiator) on patients affected by recurrent non-small-cell lung cancer (NSCLC).",

keywords = "nsclc, nsclc",

author = "Giovanna Mantini and Valeria Valentini and Bruno Meduri and Stefano Margaritora and Marinella Balducci and F Miccich{\'e} and Luigia Nardone and \{De Rose\}, Fiorenza and Alfredo Cesario and Larici, \{Anna Rita\} and F Maggi and Calcagni, \{Maria Lucia\} and Pierluigi Granone",

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doi = "10.1016/j.radonc.2012.09.006",

language = "English",

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Mantini, G, Valentini, V, Meduri, B, Margaritora, S, Balducci, M, Micciché, F, Nardone, L, De Rose, F, Cesario, A, Larici, AR, Maggi, F, Calcagni, ML & Granone, P 2012, 'Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study', Radiotherapy and Oncology, vol. 105, no. 2, pp. 161-166. https://doi.org/10.1016/j.radonc.2012.09.006

TY - JOUR

T1 - Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study

AU - Mantini, Giovanna

AU - Valentini, Valeria

AU - Meduri, Bruno

AU - Margaritora, Stefano

AU - Balducci, Marinella

AU - Micciché, F

AU - Nardone, Luigia

AU - De Rose, Fiorenza

AU - Cesario, Alfredo

AU - Larici, Anna Rita

AU - Maggi, F

AU - Calcagni, Maria Lucia

AU - Granone, Pierluigi

PY - 2012

Y1 - 2012

N2 - Low-dose radiotherapy (LDR) (<50 cGy) induces enhanced cell killing in vitro via the hyper-radiation sensitivity phenomenon. Aim of this study was to evaluate the safety and efficacy of a palliative regimen combining pemetrexed and LDR (as a chemopotentiator) on patients affected by recurrent non-small-cell lung cancer (NSCLC).

AB - Low-dose radiotherapy (LDR) (<50 cGy) induces enhanced cell killing in vitro via the hyper-radiation sensitivity phenomenon. Aim of this study was to evaluate the safety and efficacy of a palliative regimen combining pemetrexed and LDR (as a chemopotentiator) on patients affected by recurrent non-small-cell lung cancer (NSCLC).

KW - nsclc

UR - https://publicatt.unicatt.it/handle/10807/39779

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U2 - 10.1016/j.radonc.2012.09.006

DO - 10.1016/j.radonc.2012.09.006

M3 - Article

SN - 0167-8140

VL - 105

SP - 161

EP - 166

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: a prospective phase II study

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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