Low-dose aspirin qualitatively affects the vascular response to Angiotensin II in hypertensive pregnant women

Sergio Ferrazzani, Sara De Carolis, Giancarlo Paradisi, Salvatore Mancuso, Antonia Carla Testa, Alessandro Caruso, Francesco Pomini

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-four women underwent an angiotensin sensitivity test (AST) at 32.4±35 (mean±SD) weeks of gestation. They were divided into two groups according to the effective pressor dose (EPD) and were defined as AST positive (n=17) or AST negative (n=27) if the EPD was <10 or ±10 nanograms/Kg/min, respectively. A regression line of the diastolic blood pressor response to angiotensin II (A II) was obtained for each woman and the mean dose:response curve for each of the two groups was computed. The mean dose:response curves from the AST positive and AST negative groups show no difference between the intercepts (−91±8.2 vs −7.3±6.6, respectively; p NS), but significant difference between the slopes (34.3±8.9 vs 195±72; p<0.00001) and the calculated thresholds (2.6±1.0 vs 4.8±2.4; p<0.001). The administration of 100 mg per day aspirin for 7 days significantly lowered the slope of the mean dose:response curve in the AST positive group with no effect on that of the AST negative group, so resulting in two very similar regression lines. The modulating effect of low-dose aspirin indirectly confirms the role of prostanoids in the abnormal deviations of vascular reactivity in pregnancy and the possible positive effect of the drug when the thromboxane/prostacyclin ratio is unbalanced.
Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalClinical and Experimental Hypertension
Volume1992
Publication statusPublished - 1992

Keywords

  • angiotensin II
  • low-dose aspirin

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