Longitudinal analysis of HIV-1 coreceptor tropism by single and triplicate HIV-1 RNA and DNA sequencing in patients undergoing successful first-line antiretroviral therapy

Simona Di Giambenedetto, Andrea De Luca, Genny Meini, Barbara Rossetti, Claudia Bianco, Francesca Ceccherini-Silberstein, Laura Sighinolfi, Laura Monno, Antonella Castagna, Gabriella Rozera, Antonella D'Arminio Monforte, Maurizio Zazzi, M. Moroni, O. Armignacco, R. Iardino, G. Ippolito, C. F. Perno, F. Von Schloesser, A. Cozzi-Lepri, E. GirardiC. Balotta, M. Borderi, M. R. Capobianchi, P. Cinque, A. Di Biagio, N. Gianotti, G. Guaraldi, M. Lichtner, S. Marcotullio, S. Rusconi, T. Formenti, L. Galli, P. Lorenzini, A. Giacometti, A. Costantini, G. Angarano, C. Santoro, F. Maggiolo, C. Suardi, P. Viale, E. Vanino, G. Verucchi, F. Castelli, E. Quiros Roldan, C. Minardi, T. Quirino, C. Abeli, P. E. Manconi, P. Piano, J. Vecchiet, K. Falasca, D. Segala, F. Mazzotta, S. Lo Caputo, G. Cassola, G. Viscoli, A. Alessandrini, R. Piscopo, G. Mazzarello, C. Mastroianni, V. Belvisi, P. Bonfanti, I. Caramma, A. P. Castelli, M. Galli, A. Lazzarin, G. Rizzardini, M. Puoti, A. L. Ridolfo, R. Piolini, S. Salpietro, L. Carenzi, M. C. Moioli, P. Cicconi, G. Marchetti, C. Mussini, C. Puzzolante, A. Gori, G. Lapadula, N. Abrescia, A. Chirianni, M. G. Guida, M. Gargiulo, F. Baldelli, D. Francisci, G. Parruti, T. Ursini, G. Magnani, M. A. Ursitti, M. Andreoni, A. Antinori, V. Vullo, A. D'Avino, A. Ammassari, L. Gallo, E. Nicastri, R. Acinapura, M. Capozzi, R. Libertone, G. Tebano, A. Cattelan, M. S. Mura, G. Madeddu, P. Caramello, G. Di Perri, G. C. Orofino, S. Bonora, M. Sciandra, G. Pellizzer, V. Manfrin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Maraviroc has been shown to be effective in patients harbouring CCR5-tropic HIV-1. While this CCR5 antagonist has initially been used in salvage therapy, its excellent safety profile makes it ideal for antiretroviral treatment simplification strategies in patients with suppressed plasma viraemia. The aim of this study was to compare HIV-1 tropism as detected in baseline plasma RNA and peripheral blood mononuclear cell (PBMC) DNA prior to first-line therapy and to analyse tropism evolution while on successful treatment.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalJournal of Antimicrobial Chemotherapy
DOIs
Publication statusPublished - 2013

Keywords

  • HIV type 1
  • V3
  • genotype interpretation
  • gp120

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